Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3474024..3474644 Replicon chromosome
Accession NZ_CP093411
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOP53_RS16900 Protein ID WP_001280991.1
Coordinates 3474426..3474644 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOP53_RS16895 Protein ID WP_000344807.1
Coordinates 3474024..3474398 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP53_RS16885 (3469163) 3469163..3470356 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOP53_RS16890 (3470379) 3470379..3473528 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOP53_RS16895 (3474024) 3474024..3474398 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOP53_RS16900 (3474426) 3474426..3474644 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOP53_RS16905 (3474823) 3474823..3475374 + 552 WP_001278793.1 maltose O-acetyltransferase -
MOP53_RS16910 (3475492) 3475492..3475962 + 471 WP_000136183.1 YlaC family protein -
MOP53_RS16915 (3476018) 3476018..3476158 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MOP53_RS16920 (3476164) 3476164..3476424 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MOP53_RS16925 (3476649) 3476649..3478199 + 1551 WP_000213148.1 EAL domain-containing protein -
MOP53_RS16935 (3478430) 3478430..3478819 + 390 WP_000961286.1 MGMT family protein -
MOP53_RS16940 (3478852) 3478852..3479421 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238572 WP_001280991.1 NZ_CP093411:3474426-3474644 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238572 NZ_LR890405:741087-741383 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238572 WP_000344807.1 NZ_CP093411:3474024-3474398 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238572 NZ_LR890405:741385-741780 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References