Detailed information of TA system TA238562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2398133..2398655
• Replicon: chromosome
• Accession: NZ_CP093411
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: MOP53_RS11695
• Protein ID: WP_000221343.1
• Coordinates: 2398133..2398417 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: MOP53_RS11700
• Protein ID: WP_000885424.1
• Coordinates: 2398407..2398655 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP53_RS11675 (2394208)	2394208..2395716	-	1509	WP_000199409.1	FAD-dependent oxidoreductase	-
MOP53_RS11680 (2395761)	2395761..2396249	+	489	WP_001293635.1	MarR family winged helix-turn-helix transcriptional regulator	-
MOP53_RS11685 (2396442)	2396442..2397521	+	1080	WP_000954697.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
MOP53_RS11690 (2397573)	2397573..2397962	-	390	WP_000194089.1	RidA family protein	-
MOP53_RS11695 (2398133)	2398133..2398417	-	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOP53_RS11700 (2398407)	2398407..2398655	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MOP53_RS11705 (2399068)	2399068..2399421	-	354	WP_000418733.1	hypothetical protein	-
MOP53_RS11710 (2399424)	2399424..2399813	-	390	WP_001044696.1	hypothetical protein	-
MOP53_RS11715 (2400178)	2400178..2400285	+	108	Protein_2299	IS110 family transposase	-
MOP53_RS11720 (2400701)	2400701..2401033	+	333	WP_000253156.1	DUF1493 family protein	-
MOP53_RS11725 (2401308)	2401308..2401496	-	189	WP_001276021.1	DUF29 family protein	-
MOP53_RS11730 (2401909)	2401909..2402817	+	909	WP_001176641.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2396442..2405689	9247

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T238562 WP_000221343.1 NZ_CP093411:c2398417-2398133 [Salmonella enterica subsp. enterica serovar Agona]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T238562 NZ_LR890395:4019933-4020151 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT238562 WP_000885424.1 NZ_CP093411:c2398655-2398407 [Salmonella enterica subsp. enterica serovar Agona]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT238562 NZ_LR890395:4019532-4019906 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5