Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842082..842742 Replicon chromosome
Accession NZ_CP093411
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MOP53_RS04085 Protein ID WP_000244756.1
Coordinates 842329..842742 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MOP53_RS04080 Protein ID WP_000351186.1
Coordinates 842082..842348 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP53_RS04060 (838010) 838010..839443 - 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -
MOP53_RS04065 (839602) 839602..839916 + 315 WP_001182977.1 N(4)-acetylcytidine aminohydrolase -
MOP53_RS04070 (840077) 840077..840736 + 660 WP_000250289.1 hemolysin III family protein -
MOP53_RS04075 (840852) 840852..841832 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
MOP53_RS04080 (842082) 842082..842348 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MOP53_RS04085 (842329) 842329..842742 + 414 WP_000244756.1 protein YgfX Toxin
MOP53_RS04090 (842795) 842795..843316 - 522 WP_001055885.1 flavodoxin FldB -
MOP53_RS04095 (843429) 843429..844325 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MOP53_RS04100 (844349) 844349..845062 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOP53_RS04105 (845068) 845068..846801 + 1734 WP_010835035.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T238560 WP_000244756.1 NZ_CP093411:842329-842742 [Salmonella enterica subsp. enterica serovar Agona]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T238560 NZ_LR890395:1923487-1923589 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT238560 WP_000351186.1 NZ_CP093411:842082-842348 [Salmonella enterica subsp. enterica serovar Agona]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238560 NZ_LR890395:c1923596-1923451 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References