Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88676..90299 Replicon plasmid pR19.0144_302k
Accession NZ_CP093408
Organism Salmonella enterica subsp. enterica serovar Agona strain R19.0144

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag MOP55_RS24205 Protein ID WP_000088046.1
Coordinates 88974..90299 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag MOP55_RS24200 Protein ID WP_024136327.1
Coordinates 88676..88969 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP55_RS25525 83746..83877 + 132 WP_000374059.1 hypothetical protein -
MOP55_RS24170 (MOP55_24170) 84218..84499 - 282 WP_000077926.1 hypothetical protein -
MOP55_RS24175 (MOP55_24175) 84549..84740 - 192 WP_000398480.1 hypothetical protein -
MOP55_RS24180 (MOP55_24180) 84964..86136 + 1173 WP_000952349.1 IS21-like element IS21 family transposase -
MOP55_RS24185 (MOP55_24185) 86136..86933 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
MOP55_RS24190 (MOP55_24190) 86972..87307 - 336 WP_065311125.1 hypothetical protein -
MOP55_RS24195 (MOP55_24195) 87680..88072 + 393 WP_000341066.1 hypothetical protein -
MOP55_RS24200 (MOP55_24200) 88676..88969 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
MOP55_RS24205 (MOP55_24205) 88974..90299 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
MOP55_RS24210 (MOP55_24210) 90360..90566 + 207 WP_000134171.1 hypothetical protein -
MOP55_RS24215 (MOP55_24215) 90668..91078 + 411 WP_000985911.1 hypothetical protein -
MOP55_RS24220 (MOP55_24220) 91091..91906 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
MOP55_RS24225 (MOP55_24225) 92160..92585 + 426 WP_001043843.1 hypothetical protein -
MOP55_RS24230 (MOP55_24230) 93134..93442 + 309 WP_001224687.1 hypothetical protein -
MOP55_RS24235 (MOP55_24235) 93458..94315 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
MOP55_RS24240 (MOP55_24240) 94377..94580 + 204 WP_001194555.1 hypothetical protein -
MOP55_RS24245 (MOP55_24245) 94922..95278 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / sul2 / ant(3'')-Ia / lnu(F) / sul3 / tet(A) / aph(6)-Id / floR / aac(3)-IId / blaLAP-2 / blaTEM-1B / blaCTX-M-55 / qnrS13 / ARR-3 / dfrA14 - 1..302777 302777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T238558 WP_000088046.1 NZ_CP093408:88974-90299 [Salmonella enterica subsp. enterica serovar Agona]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T238558 NZ_LR890395:736758-737243 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT238558 WP_024136327.1 NZ_CP093408:88676-88969 [Salmonella enterica subsp. enterica serovar Agona]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT238558 NZ_LR890395:736468-736761 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References