Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4180145..4180695 Replicon chromosome
Accession NZ_CP093407
Organism Salmonella enterica subsp. enterica serovar Agona strain R19.0144

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MOP55_RS20420 Protein ID WP_001199743.1
Coordinates 4180145..4180453 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MOP55_RS20425 Protein ID WP_000016244.1
Coordinates 4180456..4180695 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP55_RS20400 (4175190) 4175190..4175645 + 456 WP_031602458.1 NUDIX domain-containing protein -
MOP55_RS20405 (4175936) 4175936..4177548 + 1613 Protein_4002 MobH family relaxase -
MOP55_RS20410 (4177538) 4177538..4178464 + 927 WP_000142420.1 site-specific integrase -
MOP55_RS20420 (4180145) 4180145..4180453 - 309 WP_001199743.1 CcdB family protein Toxin
MOP55_RS20425 (4180456) 4180456..4180695 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MOP55_RS20430 (4180804) 4180804..4181052 - 249 WP_000254751.1 ribbon-helix-helix domain-containing protein -
MOP55_RS20435 (4181243) 4181243..4181674 - 432 Protein_4008 helix-turn-helix domain-containing protein -
MOP55_RS20450 (4182432) 4182432..4183451 + 1020 WP_000152567.1 NAD(P)-dependent alcohol dehydrogenase -
MOP55_RS20455 (4183479) 4183479..4184009 - 531 WP_000896759.1 gluconokinase -
MOP55_RS20460 (4184226) 4184226..4185257 + 1032 WP_000453362.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA7 - 4143032..4181052 38020
- inside IScluster/Tn - - 4178510..4181629 3119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T238554 WP_001199743.1 NZ_CP093407:c4180453-4180145 [Salmonella enterica subsp. enterica serovar Agona]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T238554 NZ_LR890391:c5151294-5150911 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT238554 WP_000016244.1 NZ_CP093407:c4180695-4180456 [Salmonella enterica subsp. enterica serovar Agona]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT238554 NZ_LR890391:c5151536-5151294 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References