Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4164152..4165790 Replicon chromosome
Accession NZ_CP093407
Organism Salmonella enterica subsp. enterica serovar Agona strain R19.0144

Toxin (Protein)


Gene name hipA Uniprot ID B5F4A8
Locus tag MOP55_RS20350 Protein ID WP_001255026.1
Coordinates 4164152..4165480 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B5F4A7
Locus tag MOP55_RS20355 Protein ID WP_001099274.1
Coordinates 4165485..4165790 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP55_RS20330 (4159690) 4159690..4160673 + 984 WP_000210270.1 toll/interleukin-1 receptor domain-containing protein -
MOP55_RS20335 (4160942) 4160942..4161469 - 528 WP_001043245.1 hypothetical protein -
MOP55_RS20340 (4161466) 4161466..4162662 - 1197 WP_000542997.1 hypothetical protein -
MOP55_RS20345 (4162851) 4162851..4163840 - 990 WP_077905772.1 restriction endonuclease -
MOP55_RS20350 (4164152) 4164152..4165480 - 1329 WP_001255026.1 type II toxin-antitoxin system HipA family toxin Toxin
MOP55_RS20355 (4165485) 4165485..4165790 - 306 WP_001099274.1 helix-turn-helix transcriptional regulator Antitoxin
MOP55_RS20360 (4166537) 4166537..4167007 + 471 WP_001222753.1 hypothetical protein -
MOP55_RS20370 (4168545) 4168545..4168781 + 237 WP_001748005.1 conjugal transfer protein TraG N-terminal domain-containing protein -
MOP55_RS20375 (4168898) 4168898..4170286 - 1389 WP_000121182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA7 - 4143032..4181052 38020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50786.57 Da        Isoelectric Point: 5.0474

>T238553 WP_001255026.1 NZ_CP093407:c4165480-4164152 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T238553 NZ_LR890391:c4833712-4832795 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGTTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11362.04 Da        Isoelectric Point: 9.7765

>AT238553 WP_001099274.1 NZ_CP093407:c4165790-4165485 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW

Download         Length: 306 bp

>AT238553 NZ_LR890391:c4834476-4833718 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4S6F6

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5VUF2

References