238539

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2425567..2426089 Replicon chromosome
Accession NZ_CP093407
Organism Salmonella enterica subsp. enterica serovar Agona strain R19.0144

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MOP55_RS11890 Protein ID WP_000221343.1
Coordinates 2425567..2425851 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MOP55_RS11895 Protein ID WP_000885424.1
Coordinates 2425841..2426089 (-) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP55_RS11870 (2421642) 2421642..2423150 - 1509 WP_000199409.1 FAD-dependent oxidoreductase -
MOP55_RS11875 (2423195) 2423195..2423683 + 489 WP_001293635.1 MarR family winged helix-turn-helix transcriptional regulator -
MOP55_RS11880 (2423876) 2423876..2424955 + 1080 WP_000954697.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MOP55_RS11885 (2425007) 2425007..2425396 - 390 WP_000194089.1 RidA family protein -
MOP55_RS11890 (2425567) 2425567..2425851 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOP55_RS11895 (2425841) 2425841..2426089 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOP55_RS11900 (2426502) 2426502..2426855 - 354 WP_000418733.1 hypothetical protein -
MOP55_RS11905 (2426858) 2426858..2427247 - 390 WP_001044696.1 hypothetical protein -
MOP55_RS11910 (2427612) 2427612..2427719 + 108 Protein_2338 IS110 family transposase -
MOP55_RS11915 (2428135) 2428135..2428467 + 333 WP_000253156.1 DUF1493 family protein -
MOP55_RS11920 (2428742) 2428742..2428930 - 189 WP_001276021.1 DUF29 family protein -
MOP55_RS11925 (2429343) 2429343..2430251 + 909 WP_001176641.1 LysR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2423876..2433123 9247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-84)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T238539 WP_000221343.1 NZ_CP093407:c2425851-2425567 [Salmonella enterica subsp. enterica serovar Agona]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T238539 NZ_LR890384:c4569850-4569317 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT238539 WP_000885424.1 NZ_CP093407:c2426089-2425841 [Salmonella enterica subsp. enterica serovar Agona]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT238539 NZ_LR890384:c4570127-4569861 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4


Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References