Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 88676..90299 | Replicon | plasmid pR21.1368_265k |
| Accession | NZ_CP093406 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.1368 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | MOP56_RS24550 | Protein ID | WP_000088046.1 |
| Coordinates | 88974..90299 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | MOP56_RS24545 | Protein ID | WP_024136327.1 |
| Coordinates | 88676..88969 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOP56_RS25600 | 83746..83877 | + | 132 | WP_000374059.1 | hypothetical protein | - |
| MOP56_RS24515 (MOP56_24515) | 84218..84499 | - | 282 | WP_000077926.1 | hypothetical protein | - |
| MOP56_RS24520 (MOP56_24520) | 84549..84740 | - | 192 | WP_000398480.1 | hypothetical protein | - |
| MOP56_RS24525 (MOP56_24525) | 84964..86136 | + | 1173 | WP_000952349.1 | IS21-like element IS21 family transposase | - |
| MOP56_RS24530 (MOP56_24530) | 86136..86933 | + | 798 | WP_000544828.1 | IS21-like element IS21 family helper ATPase IstB | - |
| MOP56_RS24535 (MOP56_24535) | 86972..87307 | - | 336 | WP_065311125.1 | hypothetical protein | - |
| MOP56_RS24540 (MOP56_24540) | 87680..88072 | + | 393 | WP_000341066.1 | hypothetical protein | - |
| MOP56_RS24545 (MOP56_24545) | 88676..88969 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MOP56_RS24550 (MOP56_24550) | 88974..90299 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| MOP56_RS24555 (MOP56_24555) | 90360..90566 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| MOP56_RS24560 (MOP56_24560) | 90668..91078 | + | 411 | WP_000985911.1 | hypothetical protein | - |
| MOP56_RS24565 (MOP56_24565) | 91091..91906 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| MOP56_RS24570 (MOP56_24570) | 92160..92585 | + | 426 | WP_001043843.1 | hypothetical protein | - |
| MOP56_RS24575 (MOP56_24575) | 93134..93442 | + | 309 | WP_001224687.1 | hypothetical protein | - |
| MOP56_RS24580 (MOP56_24580) | 93458..94315 | + | 858 | WP_000784387.1 | HNH endonuclease signature motif containing protein | - |
| MOP56_RS24585 (MOP56_24585) | 94377..94580 | + | 204 | WP_001194555.1 | hypothetical protein | - |
| MOP56_RS24590 (MOP56_24590) | 94922..95278 | - | 357 | WP_065311124.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / floR / blaTEM-1B / blaLAP-2 / aac(3)-IId / ant(3'')-Ia / lnu(F) / sul3 / tet(A) / blaCTX-M-55 / qnrS13 / ARR-3 / dfrA14 | - | 1..265849 | 265849 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T238535 WP_000088046.1 NZ_CP093406:88974-90299 [Salmonella enterica subsp. enterica serovar Agona]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T238535 NZ_LR890384:1884459-1884561 [Klebsiella pneumoniae]
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT238535 WP_024136327.1 NZ_CP093406:88676-88969 [Salmonella enterica subsp. enterica serovar Agona]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT238535 NZ_LR890384:c1884568-1884423 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |