Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4239062..4239705 Replicon chromosome
Accession NZ_CP093405
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MOP56_RS20740 Protein ID WP_000048134.1
Coordinates 4239289..4239705 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MOP56_RS20735 Protein ID WP_001261294.1
Coordinates 4239062..4239292 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP56_RS20725 (4236076) 4236076..4238214 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MOP56_RS20730 (4238431) 4238431..4238895 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOP56_RS20735 (4239062) 4239062..4239292 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MOP56_RS20740 (4239289) 4239289..4239705 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MOP56_RS20745 (4239766) 4239766..4241679 - 1914 WP_001212127.1 BglG family transcription antiterminator -
MOP56_RS20750 (4241696) 4241696..4242436 - 741 WP_000779249.1 KDGP aldolase family protein -
MOP56_RS20755 (4242433) 4242433..4243551 - 1119 WP_001139179.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOP56_RS20760 (4243535) 4243535..4244668 - 1134 WP_000459942.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T238532 WP_000048134.1 NZ_CP093405:4239289-4239705 [Salmonella enterica subsp. enterica serovar Agona]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T238532 NZ_LR890384:322803-323171 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT238532 WP_001261294.1 NZ_CP093405:4239062-4239292 [Salmonella enterica subsp. enterica serovar Agona]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT238532 NZ_LR890384:322585-322806 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References