Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4197679..4198229 Replicon chromosome
Accession NZ_CP093405
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MOP56_RS20520 Protein ID WP_001199743.1
Coordinates 4197679..4197987 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MOP56_RS20525 Protein ID WP_000016244.1
Coordinates 4197990..4198229 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP56_RS20500 (4192724) 4192724..4193179 + 456 WP_031602458.1 NUDIX domain-containing protein -
MOP56_RS20505 (4193470) 4193470..4195082 + 1613 Protein_4022 MobH family relaxase -
MOP56_RS20510 (4195072) 4195072..4195998 + 927 WP_000142420.1 site-specific integrase -
MOP56_RS20520 (4197679) 4197679..4197987 - 309 WP_001199743.1 CcdB family protein Toxin
MOP56_RS20525 (4197990) 4197990..4198229 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MOP56_RS20530 (4198338) 4198338..4198586 - 249 WP_000254751.1 ribbon-helix-helix domain-containing protein -
MOP56_RS20535 (4198777) 4198777..4199208 - 432 Protein_4028 helix-turn-helix domain-containing protein -
MOP56_RS20550 (4199966) 4199966..4200985 + 1020 WP_000152567.1 NAD(P)-dependent alcohol dehydrogenase -
MOP56_RS20555 (4201013) 4201013..4201543 - 531 WP_000896759.1 gluconokinase -
MOP56_RS20560 (4201760) 4201760..4202791 + 1032 WP_000453362.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4196044..4199163 3119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T238531 WP_001199743.1 NZ_CP093405:c4197987-4197679 [Salmonella enterica subsp. enterica serovar Agona]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T238531 NZ_LR890381:c5382800-5382417 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT238531 WP_000016244.1 NZ_CP093405:c4198229-4197990 [Salmonella enterica subsp. enterica serovar Agona]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT238531 NZ_LR890381:c5383042-5382800 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References