Detailed information of TA system TA238526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3515647..3516267
• Replicon: chromosome
• Accession: NZ_CP093405
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MOP56_RS17175
• Protein ID: WP_001280991.1
• Coordinates: 3516049..3516267 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MOP56_RS17170
• Protein ID: WP_000344807.1
• Coordinates: 3515647..3516021 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP56_RS17160 (3510786)	3510786..3511979	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MOP56_RS17165 (3512002)	3512002..3515151	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
MOP56_RS17170 (3515647)	3515647..3516021	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MOP56_RS17175 (3516049)	3516049..3516267	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
MOP56_RS17180 (3516446)	3516446..3516997	+	552	WP_001278793.1	maltose O-acetyltransferase	-
MOP56_RS17185 (3517115)	3517115..3517585	+	471	WP_000136183.1	YlaC family protein	-
MOP56_RS17190 (3517641)	3517641..3517781	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
MOP56_RS17195 (3517787)	3517787..3518047	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MOP56_RS17200 (3518272)	3518272..3519822	+	1551	WP_000213148.1	EAL domain-containing protein	-
MOP56_RS17210 (3520053)	3520053..3520442	+	390	WP_000961286.1	MGMT family protein	-
MOP56_RS17215 (3520475)	3520475..3521044	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T238526 WP_001280991.1 NZ_CP093405:3516049-3516267 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T238526 NZ_LR890381:3970387-3970605 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT238526 WP_000344807.1 NZ_CP093405:3515647-3516021 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT238526 NZ_LR890381:3969986-3970360 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0