Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515647..3516267 Replicon chromosome
Accession NZ_CP093405
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOP56_RS17175 Protein ID WP_001280991.1
Coordinates 3516049..3516267 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOP56_RS17170 Protein ID WP_000344807.1
Coordinates 3515647..3516021 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP56_RS17160 (3510786) 3510786..3511979 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOP56_RS17165 (3512002) 3512002..3515151 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOP56_RS17170 (3515647) 3515647..3516021 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOP56_RS17175 (3516049) 3516049..3516267 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOP56_RS17180 (3516446) 3516446..3516997 + 552 WP_001278793.1 maltose O-acetyltransferase -
MOP56_RS17185 (3517115) 3517115..3517585 + 471 WP_000136183.1 YlaC family protein -
MOP56_RS17190 (3517641) 3517641..3517781 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MOP56_RS17195 (3517787) 3517787..3518047 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MOP56_RS17200 (3518272) 3518272..3519822 + 1551 WP_000213148.1 EAL domain-containing protein -
MOP56_RS17210 (3520053) 3520053..3520442 + 390 WP_000961286.1 MGMT family protein -
MOP56_RS17215 (3520475) 3520475..3521044 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238526 WP_001280991.1 NZ_CP093405:3516049-3516267 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238526 NZ_LR890381:3970387-3970605 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238526 WP_000344807.1 NZ_CP093405:3515647-3516021 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238526 NZ_LR890381:3969986-3970360 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References