Detailed information of TA system TA238516

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2439756..2440278
• Replicon: chromosome
• Accession: NZ_CP093405
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: MOP56_RS11970
• Protein ID: WP_000221343.1
• Coordinates: 2439756..2440040 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: MOP56_RS11975
• Protein ID: WP_000885424.1
• Coordinates: 2440030..2440278 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP56_RS11950 (2435831)	2435831..2437339	-	1509	WP_000199409.1	FAD-dependent oxidoreductase	-
MOP56_RS11955 (2437384)	2437384..2437872	+	489	WP_001293635.1	MarR family winged helix-turn-helix transcriptional regulator	-
MOP56_RS11960 (2438065)	2438065..2439144	+	1080	WP_000954697.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
MOP56_RS11965 (2439196)	2439196..2439585	-	390	WP_000194089.1	RidA family protein	-
MOP56_RS11970 (2439756)	2439756..2440040	-	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOP56_RS11975 (2440030)	2440030..2440278	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MOP56_RS11980 (2440691)	2440691..2441044	-	354	WP_000418733.1	hypothetical protein	-
MOP56_RS11985 (2441047)	2441047..2441436	-	390	WP_001044696.1	hypothetical protein	-
MOP56_RS11990 (2441801)	2441801..2441908	+	108	Protein_2354	IS110 family transposase	-
MOP56_RS11995 (2442324)	2442324..2442656	+	333	WP_000253156.1	DUF1493 family protein	-
MOP56_RS12000 (2442931)	2442931..2443119	-	189	WP_001276021.1	DUF29 family protein	-
MOP56_RS12005 (2443532)	2443532..2444440	+	909	WP_001176641.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2438065..2447312	9247

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T238516 WP_000221343.1 NZ_CP093405:c2440040-2439756 [Salmonella enterica subsp. enterica serovar Agona]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T238516 NZ_LR890376:c20853-20437 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT238516 WP_000885424.1 NZ_CP093405:c2440278-2440030 [Salmonella enterica subsp. enterica serovar Agona]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT238516 NZ_LR890376:c21080-20850 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5