Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 886150..886810 Replicon chromosome
Accession NZ_CP093405
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MOP56_RS04370 Protein ID WP_000244756.1
Coordinates 886397..886810 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MOP56_RS04365 Protein ID WP_000351186.1
Coordinates 886150..886416 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP56_RS04345 (882078) 882078..883511 - 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -
MOP56_RS04350 (883670) 883670..883984 + 315 WP_001182977.1 N(4)-acetylcytidine aminohydrolase -
MOP56_RS04355 (884145) 884145..884804 + 660 WP_000250289.1 hemolysin III family protein -
MOP56_RS04360 (884920) 884920..885900 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
MOP56_RS04365 (886150) 886150..886416 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MOP56_RS04370 (886397) 886397..886810 + 414 WP_000244756.1 protein YgfX Toxin
MOP56_RS04375 (886863) 886863..887384 - 522 WP_001055885.1 flavodoxin FldB -
MOP56_RS04380 (887497) 887497..888393 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MOP56_RS04385 (888417) 888417..889130 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOP56_RS04390 (889136) 889136..890869 + 1734 WP_010835035.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T238514 WP_000244756.1 NZ_CP093405:886397-886810 [Salmonella enterica subsp. enterica serovar Agona]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T238514 NZ_LR890374:c5185499-5185116 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT238514 WP_000351186.1 NZ_CP093405:886150-886416 [Salmonella enterica subsp. enterica serovar Agona]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238514 NZ_LR890374:c5185741-5185499 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References