238510

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4221953..4222596 Replicon chromosome
Accession NZ_CP093403
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1436

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MOP57_RS20640 Protein ID WP_000048134.1
Coordinates 4222180..4222596 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MOP57_RS20635 Protein ID WP_001261294.1
Coordinates 4221953..4222183 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP57_RS20625 (4218967) 4218967..4221105 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MOP57_RS20630 (4221322) 4221322..4221786 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOP57_RS20635 (4221953) 4221953..4222183 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MOP57_RS20640 (4222180) 4222180..4222596 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MOP57_RS20645 (4222657) 4222657..4224570 - 1914 WP_001212127.1 BglG family transcription antiterminator -
MOP57_RS20650 (4224587) 4224587..4225327 - 741 WP_000779249.1 KDGP aldolase family protein -
MOP57_RS20655 (4225324) 4225324..4226442 - 1119 WP_001139179.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOP57_RS20660 (4226426) 4226426..4227559 - 1134 WP_000459942.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T238510 WP_000048134.1 NZ_CP093403:4222180-4222596 [Salmonella enterica subsp. enterica serovar Agona]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T238510 NZ_LR890374:4033237-4033455 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT238510 WP_001261294.1 NZ_CP093403:4221953-4222183 [Salmonella enterica subsp. enterica serovar Agona]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT238510 NZ_LR890374:4032836-4033210 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References