238508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4164577..4166215 Replicon chromosome
Accession NZ_CP093403
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1436

Toxin (Protein)


Gene name hipA Uniprot ID B5F4A8
Locus tag MOP57_RS20350 Protein ID WP_001255026.1
Coordinates 4164577..4165905 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B5F4A7
Locus tag MOP57_RS20355 Protein ID WP_001099274.1
Coordinates 4165910..4166215 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP57_RS20330 (4160115) 4160115..4161098 + 984 WP_000210270.1 toll/interleukin-1 receptor domain-containing protein -
MOP57_RS20335 (4161367) 4161367..4161894 - 528 WP_001043245.1 hypothetical protein -
MOP57_RS20340 (4161891) 4161891..4163087 - 1197 WP_000542997.1 hypothetical protein -
MOP57_RS20345 (4163276) 4163276..4164265 - 990 WP_077905772.1 restriction endonuclease -
MOP57_RS20350 (4164577) 4164577..4165905 - 1329 WP_001255026.1 type II toxin-antitoxin system HipA family toxin Toxin
MOP57_RS20355 (4165910) 4165910..4166215 - 306 WP_001099274.1 helix-turn-helix transcriptional regulator Antitoxin
MOP57_RS20360 (4166962) 4166962..4167432 + 471 WP_001222753.1 hypothetical protein -
MOP57_RS20370 (4168970) 4168970..4169206 + 237 WP_001748005.1 conjugal transfer protein TraG N-terminal domain-containing protein -
MOP57_RS20375 (4169323) 4169323..4170711 - 1389 WP_000121182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA7 - 4143457..4173688 30231


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50786.57 Da        Isoelectric Point: 5.0474

>T238508 WP_001255026.1 NZ_CP093403:c4165905-4164577 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T238508 NZ_LR890374:1935303-1935405 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11362.04 Da        Isoelectric Point: 9.7765

>AT238508 WP_001099274.1 NZ_CP093403:c4166215-4165910 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW

Download         Length: 306 bp

>AT238508 NZ_LR890374:c1935412-1935267 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4S6F6

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5VUF2

References