Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3501883..3502503 Replicon chromosome
Accession NZ_CP093403
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.1436

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOP57_RS17095 Protein ID WP_001280991.1
Coordinates 3502285..3502503 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOP57_RS17090 Protein ID WP_000344807.1
Coordinates 3501883..3502257 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP57_RS17080 (3497022) 3497022..3498215 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOP57_RS17085 (3498238) 3498238..3501387 + 3150 WP_242165833.1 efflux RND transporter permease AcrB -
MOP57_RS17090 (3501883) 3501883..3502257 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOP57_RS17095 (3502285) 3502285..3502503 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOP57_RS17100 (3502682) 3502682..3503233 + 552 WP_001278793.1 maltose O-acetyltransferase -
MOP57_RS17105 (3503351) 3503351..3503821 + 471 WP_000136183.1 YlaC family protein -
MOP57_RS17110 (3503877) 3503877..3504017 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MOP57_RS17115 (3504023) 3504023..3504283 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MOP57_RS17120 (3504508) 3504508..3506058 + 1551 WP_000213148.1 EAL domain-containing protein -
MOP57_RS17130 (3506289) 3506289..3506678 + 390 WP_000961286.1 MGMT family protein -
MOP57_RS17135 (3506711) 3506711..3507280 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238504 WP_001280991.1 NZ_CP093403:3502285-3502503 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238504 NZ_LR890374:364227-364574 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238504 WP_000344807.1 NZ_CP093403:3501883-3502257 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238504 NZ_LR890374:364574-364873 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References