Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4316753..4317396 Replicon chromosome
Accession NZ_CP093402
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MOP58_RS21235 Protein ID WP_000048134.1
Coordinates 4316980..4317396 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MOP58_RS21230 Protein ID WP_001261294.1
Coordinates 4316753..4316983 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP58_RS21220 (4313767) 4313767..4315905 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MOP58_RS21225 (4316122) 4316122..4316586 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOP58_RS21230 (4316753) 4316753..4316983 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MOP58_RS21235 (4316980) 4316980..4317396 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MOP58_RS21240 (4317457) 4317457..4319370 - 1914 WP_001212127.1 BglG family transcription antiterminator -
MOP58_RS21245 (4319387) 4319387..4320127 - 741 WP_000779249.1 KDGP aldolase family protein -
MOP58_RS21250 (4320124) 4320124..4321242 - 1119 WP_001139179.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOP58_RS21255 (4321226) 4321226..4322359 - 1134 WP_000459942.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T238488 WP_000048134.1 NZ_CP093402:4316980-4317396 [Salmonella enterica subsp. enterica serovar Agona]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T238488 NZ_LR890369:723135-723620 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT238488 WP_001261294.1 NZ_CP093402:4316753-4316983 [Salmonella enterica subsp. enterica serovar Agona]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT238488 NZ_LR890369:722845-723138 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References