238487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4275370..4275920 Replicon chromosome
Accession NZ_CP093402
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MOP58_RS21015 Protein ID WP_001199743.1
Coordinates 4275370..4275678 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MOP58_RS21020 Protein ID WP_000016244.1
Coordinates 4275681..4275920 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP58_RS20995 (4270415) 4270415..4270870 + 456 WP_031602458.1 NUDIX domain-containing protein -
MOP58_RS21000 (4271161) 4271161..4272773 + 1613 Protein_4121 MobH family relaxase -
MOP58_RS21005 (4272763) 4272763..4273689 + 927 WP_000142420.1 site-specific integrase -
MOP58_RS21015 (4275370) 4275370..4275678 - 309 WP_001199743.1 CcdB family protein Toxin
MOP58_RS21020 (4275681) 4275681..4275920 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MOP58_RS21025 (4276029) 4276029..4276277 - 249 WP_000254751.1 ribbon-helix-helix domain-containing protein -
MOP58_RS21030 (4276468) 4276468..4276899 - 432 Protein_4127 helix-turn-helix domain-containing protein -
MOP58_RS21045 (4277657) 4277657..4278676 + 1020 WP_000152567.1 NAD(P)-dependent alcohol dehydrogenase -
MOP58_RS21050 (4278704) 4278704..4279234 - 531 WP_000896759.1 gluconokinase -
MOP58_RS21055 (4279451) 4279451..4280482 + 1032 WP_000453362.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4273735..4276854 3119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T238487 WP_001199743.1 NZ_CP093402:c4275678-4275370 [Salmonella enterica subsp. enterica serovar Agona]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T238487 NZ_LR890369:365293-365640 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT238487 WP_000016244.1 NZ_CP093402:c4275920-4275681 [Salmonella enterica subsp. enterica serovar Agona]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT238487 NZ_LR890369:365640-365939 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References