Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3596683..3597303 Replicon chromosome
Accession NZ_CP093402
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOP58_RS17690 Protein ID WP_001280991.1
Coordinates 3597085..3597303 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOP58_RS17685 Protein ID WP_000344807.1
Coordinates 3596683..3597057 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP58_RS17675 (3591822) 3591822..3593015 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOP58_RS17680 (3593038) 3593038..3596187 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOP58_RS17685 (3596683) 3596683..3597057 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOP58_RS17690 (3597085) 3597085..3597303 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOP58_RS17695 (3597482) 3597482..3598033 + 552 WP_001278793.1 maltose O-acetyltransferase -
MOP58_RS17700 (3598151) 3598151..3598621 + 471 WP_000136183.1 YlaC family protein -
MOP58_RS17705 (3598677) 3598677..3598817 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MOP58_RS17710 (3598823) 3598823..3599083 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MOP58_RS17715 (3599308) 3599308..3600858 + 1551 WP_000213148.1 EAL domain-containing protein -
MOP58_RS17725 (3601089) 3601089..3601478 + 390 WP_000961286.1 MGMT family protein -
MOP58_RS17730 (3601511) 3601511..3602080 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238482 WP_001280991.1 NZ_CP093402:3597085-3597303 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238482 NZ_LR890361:34771-35187 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238482 WP_000344807.1 NZ_CP093402:3596683-3597057 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238482 NZ_LR890361:34544-34774 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References