Detailed information of TA system TA238482

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3596683..3597303
• Replicon: chromosome
• Accession: NZ_CP093402
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MOP58_RS17690
• Protein ID: WP_001280991.1
• Coordinates: 3597085..3597303 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MOP58_RS17685
• Protein ID: WP_000344807.1
• Coordinates: 3596683..3597057 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP58_RS17675 (3591822)	3591822..3593015	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MOP58_RS17680 (3593038)	3593038..3596187	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
MOP58_RS17685 (3596683)	3596683..3597057	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MOP58_RS17690 (3597085)	3597085..3597303	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
MOP58_RS17695 (3597482)	3597482..3598033	+	552	WP_001278793.1	maltose O-acetyltransferase	-
MOP58_RS17700 (3598151)	3598151..3598621	+	471	WP_000136183.1	YlaC family protein	-
MOP58_RS17705 (3598677)	3598677..3598817	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
MOP58_RS17710 (3598823)	3598823..3599083	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MOP58_RS17715 (3599308)	3599308..3600858	+	1551	WP_000213148.1	EAL domain-containing protein	-
MOP58_RS17725 (3601089)	3601089..3601478	+	390	WP_000961286.1	MGMT family protein	-
MOP58_RS17730 (3601511)	3601511..3602080	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T238482 WP_001280991.1 NZ_CP093402:3597085-3597303 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T238482 NZ_LR890361:34771-35187 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT238482 WP_000344807.1 NZ_CP093402:3596683-3597057 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT238482 NZ_LR890361:34544-34774 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0