238472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2520792..2521314 Replicon chromosome
Accession NZ_CP093402
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MOP58_RS12485 Protein ID WP_000221343.1
Coordinates 2520792..2521076 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MOP58_RS12490 Protein ID WP_000885424.1
Coordinates 2521066..2521314 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP58_RS12465 (2516867) 2516867..2518375 - 1509 WP_000199409.1 FAD-dependent oxidoreductase -
MOP58_RS12470 (2518420) 2518420..2518908 + 489 WP_001293635.1 MarR family winged helix-turn-helix transcriptional regulator -
MOP58_RS12475 (2519101) 2519101..2520180 + 1080 WP_000954697.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MOP58_RS12480 (2520232) 2520232..2520621 - 390 WP_000194089.1 RidA family protein -
MOP58_RS12485 (2520792) 2520792..2521076 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOP58_RS12490 (2521066) 2521066..2521314 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOP58_RS12495 (2521727) 2521727..2522080 - 354 WP_000418733.1 hypothetical protein -
MOP58_RS12500 (2522083) 2522083..2522472 - 390 WP_001044696.1 hypothetical protein -
MOP58_RS12505 (2522837) 2522837..2522944 + 108 Protein_2457 IS110 family transposase -
MOP58_RS12510 (2523360) 2523360..2523692 + 333 WP_000253156.1 DUF1493 family protein -
MOP58_RS12515 (2523967) 2523967..2524155 - 189 WP_001276021.1 DUF29 family protein -
MOP58_RS12520 (2524568) 2524568..2525476 + 909 WP_001176641.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2519101..2528348 9247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T238472 WP_000221343.1 NZ_CP093402:c2521076-2520792 [Salmonella enterica subsp. enterica serovar Agona]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T238472 NZ_LR890360:1829477-1829579 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT238472 WP_000885424.1 NZ_CP093402:c2521314-2521066 [Salmonella enterica subsp. enterica serovar Agona]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT238472 NZ_LR890360:c1829586-1829441 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References