Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 49897..50422 | Replicon | plasmid pR21.1147_195k |
| Accession | NZ_CP093401 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain R21.1147 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A5Y5FBU7 |
| Locus tag | MOP59_RS23945 | Protein ID | WP_023994134.1 |
| Coordinates | 50117..50422 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A5T8X4Y4 |
| Locus tag | MOP59_RS23940 | Protein ID | WP_023994135.1 |
| Coordinates | 49897..50115 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOP59_RS23905 (MOP59_23905) | 44929..45693 | + | 765 | WP_023994141.1 | minor fimbrial protein | - |
| MOP59_RS23910 (MOP59_23910) | 45896..46486 | + | 591 | WP_023994140.1 | hypothetical protein | - |
| MOP59_RS23915 (MOP59_23915) | 46552..46764 | + | 213 | WP_023994139.1 | FaeA/PapI family transcriptional regulator | - |
| MOP59_RS23920 (MOP59_23920) | 47025..47186 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| MOP59_RS23925 (MOP59_23925) | 47212..48060 | + | 849 | WP_023994138.1 | SdiA-regulated domain-containing protein | - |
| MOP59_RS23930 (MOP59_23930) | 48630..49046 | - | 417 | WP_023994137.1 | type II toxin-antitoxin system VapC family toxin | - |
| MOP59_RS23935 (MOP59_23935) | 49043..49273 | - | 231 | WP_023994136.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MOP59_RS23940 (MOP59_23940) | 49897..50115 | + | 219 | WP_023994135.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| MOP59_RS23945 (MOP59_23945) | 50117..50422 | + | 306 | WP_023994134.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| MOP59_RS23950 (MOP59_23950) | 50424..50714 | + | 291 | WP_023994133.1 | hypothetical protein | - |
| MOP59_RS24610 | 50711..50986 | + | 276 | Protein_59 | 3'-5' exonuclease | - |
| MOP59_RS23965 (MOP59_23965) | 51057..51173 | + | 117 | Protein_60 | hypothetical protein | - |
| MOP59_RS23970 (MOP59_23970) | 51163..51878 | - | 716 | Protein_61 | transposase | - |
| MOP59_RS23975 (MOP59_23975) | 53160..53696 | + | 537 | WP_023994130.1 | fimbrial protein | - |
| MOP59_RS23980 (MOP59_23980) | 53749..54480 | + | 732 | WP_023994129.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | floR / aph(4)-Ia / aac(3)-IVa / dfrA14 / aph(3')-Ia | faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..195315 | 195315 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11708.47 Da Isoelectric Point: 6.4685
>T238468 WP_023994134.1 NZ_CP093401:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
MQFKVYTYKRESRYRLFVDVQSDIVDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASFIGEEV
AELSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIVDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASFIGEEV
AELSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T238468 NZ_LR890357:86659-86964 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTATATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCACCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTATATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCACCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8261.18 Da Isoelectric Point: 4.7405
>AT238468 WP_023994135.1 NZ_CP093401:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEANGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEANGSFADENRDW
Download Length: 219 bp
>AT238468 NZ_LR890357:86439-86657 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y5FBU7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T8X4Y4 |