Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 14531..15121 Replicon plasmid pR21.1147_195k
Accession NZ_CP093401
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag MOP59_RS23725 Protein ID WP_023994178.1
Coordinates 14789..15121 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag MOP59_RS23720 Protein ID WP_023994179.1
Coordinates 14531..14788 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP59_RS23700 (MOP59_23700) 10030..11055 + 1026 WP_023994180.1 IS630 family transposase -
MOP59_RS23705 (MOP59_23705) 11059..12078 - 1020 WP_223155817.1 hypothetical protein -
MOP59_RS23710 (MOP59_23710) 12218..12724 - 507 WP_223155815.1 hypothetical protein -
MOP59_RS23715 (MOP59_23715) 12835..13920 - 1086 WP_223155813.1 hypothetical protein -
MOP59_RS23720 (MOP59_23720) 14531..14788 + 258 WP_023994179.1 hypothetical protein Antitoxin
MOP59_RS23725 (MOP59_23725) 14789..15121 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MOP59_RS23730 (MOP59_23730) 15721..16326 + 606 Protein_14 IS481 family transposase -
MOP59_RS23735 (MOP59_23735) 16625..18847 - 2223 WP_242211999.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR / aph(4)-Ia / aac(3)-IVa / dfrA14 / aph(3')-Ia faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..195315 195315
- inside IScluster/Tn - - 10018..16326 6308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11787.54 Da        Isoelectric Point: 9.3417

>T238465 WP_023994178.1 NZ_CP093401:14789-15121 [Salmonella enterica subsp. enterica serovar Infantis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

>T238465 NZ_LR890356:c5356388-5356005 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9374.86 Da        Isoelectric Point: 4.4354

>AT238465 WP_023994179.1 NZ_CP093401:14531-14788 [Salmonella enterica subsp. enterica serovar Infantis]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL

Download         Length: 258 bp

>AT238465 NZ_LR890356:c5356630-5356388 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References