Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 4182822..4183338 Replicon chromosome
Accession NZ_CP093400
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag MOP59_RS20425 Protein ID WP_023993574.1
Coordinates 4182822..4183106 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag MOP59_RS20430 Protein ID WP_023993575.1
Coordinates 4183096..4183338 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP59_RS20410 (4177938) 4177938..4179590 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
MOP59_RS20415 (4179999) 4179999..4182137 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
MOP59_RS20420 (4182354) 4182354..4182818 + 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOP59_RS20425 (4182822) 4182822..4183106 - 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOP59_RS20430 (4183096) 4183096..4183338 - 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOP59_RS20435 (4183416) 4183416..4185329 - 1914 WP_023993576.1 BglG family transcription antiterminator -
MOP59_RS20440 (4185346) 4185346..4186086 - 741 WP_023993577.1 KDGP aldolase family protein -
MOP59_RS20445 (4186083) 4186083..4187201 - 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOP59_RS20450 (4187185) 4187185..4188318 - 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T238462 WP_023993574.1 NZ_CP093400:c4183106-4182822 [Salmonella enterica subsp. enterica serovar Infantis]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T238462 NZ_LR890356:4159427-4159645 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT238462 WP_023993575.1 NZ_CP093400:c4183338-4183096 [Salmonella enterica subsp. enterica serovar Infantis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp

>AT238462 NZ_LR890356:4159026-4159400 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References