Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2298127..2298649 Replicon chromosome
Accession NZ_CP093400
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MOP59_RS11200 Protein ID WP_000221343.1
Coordinates 2298127..2298411 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag MOP59_RS11205 Protein ID WP_000885426.1
Coordinates 2298401..2298649 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP59_RS11180 (2294206) 2294206..2295714 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
MOP59_RS11185 (2295759) 2295759..2296247 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
MOP59_RS11190 (2296440) 2296440..2297519 + 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MOP59_RS11195 (2297567) 2297567..2297956 - 390 WP_023993262.1 RidA family protein -
MOP59_RS11200 (2298127) 2298127..2298411 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOP59_RS11205 (2298401) 2298401..2298649 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOP59_RS11210 (2298801) 2298801..2299016 + 216 WP_023993263.1 phage protein -
MOP59_RS11215 (2299006) 2299006..2299338 + 333 WP_000253154.1 DUF1493 family protein -
MOP59_RS11220 (2299618) 2299618..2299812 + 195 Protein_2202 hypothetical protein -
MOP59_RS11225 (2299811) 2299811..2300257 - 447 Protein_2203 helix-turn-helix domain-containing protein -
MOP59_RS11230 (2301163) 2301163..2302071 + 909 WP_242211998.1 LysR family transcriptional regulator -
MOP59_RS11235 (2302245) 2302245..2303225 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2292769..2304954 12185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T238449 WP_000221343.1 NZ_CP093400:c2298411-2298127 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T238449 NZ_LR890349:2176154-2176257 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT238449 WP_000885426.1 NZ_CP093400:c2298649-2298401 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT238449 NZ_LR890349:c2176295-2176027 [Escherichia coli]
AAAGTCAGCGAAGGGAATGTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References