Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1563730..1564373 Replicon chromosome
Accession NZ_CP093400
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag MOP59_RS07490 Protein ID WP_001044768.1
Coordinates 1563730..1564146 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag MOP59_RS07495 Protein ID WP_001261287.1
Coordinates 1564143..1564373 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP59_RS07475 (1560229) 1560229..1560819 - 591 WP_000194575.1 hypothetical protein -
MOP59_RS07480 (1560819) 1560819..1561076 - 258 WP_000343085.1 hypothetical protein -
MOP59_RS07485 (1561430) 1561430..1563568 + 2139 WP_075322282.1 AAA family ATPase -
MOP59_RS07490 (1563730) 1563730..1564146 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
MOP59_RS07495 (1564143) 1564143..1564373 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MOP59_RS07500 (1564681) 1564681..1566246 + 1566 WP_000741348.1 AAA family ATPase -
MOP59_RS07505 (1566303) 1566303..1567172 - 870 WP_000253407.1 hypothetical protein -
MOP59_RS07510 (1567174) 1567174..1568262 - 1089 WP_000952231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaCTX-M-65 - 1541294..1642855 101561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T238446 WP_001044768.1 NZ_CP093400:c1564146-1563730 [Salmonella enterica subsp. enterica serovar Infantis]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T238446 NZ_LR890349:793631-793927 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT238446 WP_001261287.1 NZ_CP093400:c1564373-1564143 [Salmonella enterica subsp. enterica serovar Infantis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT238446 NZ_LR890349:793929-794324 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References