Detailed information of TA system TA238444

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 846862..847522
• Replicon: chromosome
• Accession: NZ_CP093400
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A5I5GR00
• Locus tag: MOP59_RS04055
• Protein ID: WP_000244761.1
• Coordinates: 847109..847522 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: MOP59_RS04050
• Protein ID: WP_000351186.1
• Coordinates: 846862..847128 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP59_RS04030 (842791)	842791..844224	-	1434	WP_001230139.1	6-phospho-beta-glucosidase BglA	-
MOP59_RS04035 (844382)	844382..844693	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
MOP59_RS04040 (844857)	844857..845516	+	660	WP_000250289.1	hemolysin III family protein	-
MOP59_RS04045 (845632)	845632..846612	-	981	WP_023260866.1	tRNA-modifying protein YgfZ	-
MOP59_RS04050 (846862)	846862..847128	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
MOP59_RS04055 (847109)	847109..847522	+	414	WP_000244761.1	protein YgfX	Toxin
MOP59_RS04060 (847575)	847575..848096	-	522	WP_001055885.1	flavodoxin FldB	-
MOP59_RS04065 (848209)	848209..849105	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
MOP59_RS04070 (849129)	849129..849842	+	714	WP_000745614.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MOP59_RS04075 (849848)	849848..851581	+	1734	WP_000813387.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16199.15 Da
• Isoelectric Point: 10.7537

>T238444 WP_000244761.1 NZ_CP093400:847109-847522 [Salmonella enterica subsp. enterica serovar Infantis]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T238444 NZ_LR890349:c680139-679675 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT238444 WP_000351186.1 NZ_CP093400:846862-847128 [Salmonella enterica subsp. enterica serovar Infantis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT238444 NZ_LR890349:c680474-680139 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A5I5GR00

Antitoxin

• AlphaFold DB: A0A5I0YWH4