Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204297..205057 Replicon chromosome
Accession NZ_CP093400
Organism Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MOP59_RS00950 Protein ID WP_000533909.1
Coordinates 204572..205057 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MOP59_RS00945 Protein ID WP_000965886.1
Coordinates 204297..204584 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP59_RS00925 (201000) 201000..201428 + 429 Protein_184 IS3 family transposase -
MOP59_RS00930 (201547) 201547..202197 - 651 WP_023993641.1 GntR family transcriptional regulator -
MOP59_RS00935 (202282) 202282..203484 + 1203 WP_023201740.1 MFS transporter -
MOP59_RS00940 (203573) 203573..204131 + 559 Protein_187 cysteine hydrolase -
MOP59_RS00945 (204297) 204297..204584 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MOP59_RS00950 (204572) 204572..205057 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MOP59_RS00955 (205429) 205429..205968 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
MOP59_RS00960 (206142) 206142..206354 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MOP59_RS00965 (206642) 206642..206932 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MOP59_RS00970 (207371) 207371..208081 + 711 WP_000190524.1 DUF3053 domain-containing protein -
MOP59_RS00975 (208131) 208131..209105 - 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
MOP59_RS00980 (209324) 209324..209986 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T238442 WP_000533909.1 NZ_CP093400:204572-205057 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T238442 NZ_LR890349:c48480-48139 [Escherichia coli]
ATGAAACCTCAATCTGCAACAATTTCGCGGGCGGCGAAGCCTTGCCTGTCGCCCGTGGCAGTCTGGCAAATGCTGCTGAT
CCGACTGCTCGAAAAGCACTATGGCCTGACGCTAAACGACACCCCGTTCAGTGATGAAACTGTGATTCAGGAACACATTA
ATGCCGGGATCACTCTGGCCGATGCTGTGAATTTTCTGGTGGAGAAATACGAACTAGTGCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCCCCTTATCTTCGGGCTGTCGATATTCTGCGAGCGCGACAGGCAACTGGCCTGTTGCGACGAAA
TCGAAAACACACTGCATTGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT238442 WP_000965886.1 NZ_CP093400:204297-204584 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT238442 NZ_LR890349:c48818-48501 [Escherichia coli]
ATGAGCAATATCACATGGGGCCTGCAGCGGGATATCACGCCGCGTCTGGGAGTCCGTCTGGTGCAGGAGGGCAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACCCCGAATGCCGGAAGTTGGATGAAACTTTCCCGC
ACTTTATCAGCCAGATGGAATTAATGCTGACTACCGGTGAACTGAATCCCCGCCATACCCACTGCATTGCCCTGTACCAC
AATGGTTTTACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References