Detailed information of TA system TA238438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1012652..1013873
• Replicon: chromosome
• Accession: NZ_CP093395
• Organism: Pseudomonas aeruginosa strain PA1_NCHU

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MON07_RS04795
• Protein ID: WP_003102740.1
• Coordinates: 1012652..1013230 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MON07_RS04800
• Protein ID: WP_003088112.1
• Coordinates: 1013319..1013873 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MON07_RS04780 (MON07_04780)	1007928..1009205	+	1278	WP_003122808.1	TolC family protein	-
MON07_RS04785 (MON07_04785)	1009195..1011366	+	2172	WP_009876279.1	type I secretion system permease/ATPase	-
MON07_RS04790 (MON07_04790)	1011356..1012543	+	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MON07_RS04795 (MON07_04795)	1012652..1013230	-	579	WP_003102740.1	HD domain-containing protein	Toxin
MON07_RS04800 (MON07_04800)	1013319..1013873	-	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MON07_RS04805 (MON07_04805)	1014031..1016226	-	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MON07_RS04810 (MON07_04810)	1016231..1016692	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MON07_RS04815 (MON07_04815)	1017023..1017346	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
MON07_RS04820 (MON07_04820)	1017359..1017757	+	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
MON07_RS04825 (MON07_04825)	1017754..1018305	-	552	WP_003102727.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T238438 WP_003102740.1 NZ_CP093395:c1013230-1012652 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T238438 NZ_LR890343:4307975-4308343 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT238438 WP_003088112.1 NZ_CP093395:c1013873-1013319 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT238438 NZ_LR890343:4307757-4307978 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07