Detailed information of TA system TA238437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 71896..73153
• Replicon: chromosome
• Accession: NZ_CP093395
• Organism: Pseudomonas aeruginosa strain PA1_NCHU

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MON07_RS00395
• Protein ID: WP_003449003.1
• Coordinates: 72398..73153 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MON07_RS00390
• Protein ID: WP_003086329.1
• Coordinates: 71896..72264 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MON07_RS00370 (MON07_00370)	68059..68334	+	276	WP_010792073.1	zinc ribbon domain-containing protein	-
MON07_RS00375 (MON07_00375)	68337..68813	-	477	WP_003112531.1	hypothetical protein	-
MON07_RS00380 (MON07_00380)	68988..70481	+	1494	WP_031630127.1	aldehyde dehydrogenase family protein	-
MON07_RS00385 (MON07_00385)	70537..71823	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
MON07_RS00390 (MON07_00390)	71896..72264	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MON07_RS00395 (MON07_00395)	72398..73153	+	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
MON07_RS00400 (MON07_00400)	73921..75282	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
MON07_RS00405 (MON07_00405)	75437..77980	-	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T238437 WP_003449003.1 NZ_CP093395:72398-73153 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T238437 NZ_LR890343:c3907280-3906897 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT238437 WP_003086329.1 NZ_CP093395:71896-72264 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT238437 NZ_LR890343:c3907522-3907280 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7