Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 8365..8866 Replicon plasmid unnamed
Accession NZ_CP093393
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name TsxA Uniprot ID A0A2S5RIK4
Locus tag MOV21_RS23150 Protein ID WP_022645141.1
Coordinates 8365..8625 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID A0A2S5RIE4
Locus tag MOV21_RS23155 Protein ID WP_022645142.1
Coordinates 8615..8866 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS23105 (MOV21_23105) 3907..4059 + 153 Protein_2 DUF5431 family protein -
MOV21_RS23110 (MOV21_23110) 4004..4126 + 123 WP_223202818.1 Hok/Gef family protein -
MOV21_RS23115 (MOV21_23115) 4276..4872 + 597 WP_000125164.1 ProQ/FINO family protein -
MOV21_RS23120 (MOV21_23120) 4890..5174 - 285 WP_001162371.1 hypothetical protein -
MOV21_RS23125 (MOV21_23125) 5248..5913 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
MOV21_RS23130 (MOV21_23130) 6510..6839 + 330 WP_000855121.1 hypothetical protein -
MOV21_RS23135 (MOV21_23135) 7418..7741 + 324 WP_000427402.1 hypothetical protein -
MOV21_RS23140 (MOV21_23140) 7782..7991 + 210 WP_000866037.1 hypothetical protein -
MOV21_RS23145 (MOV21_23145) 8089..8313 + 225 WP_000814383.1 hypothetical protein -
MOV21_RS23150 (MOV21_23150) 8365..8625 + 261 WP_022645141.1 hypothetical protein Toxin
MOV21_RS23155 (MOV21_23155) 8615..8866 + 252 WP_022645142.1 transcriptional regulator Antitoxin
MOV21_RS23160 (MOV21_23160) 9416..9694 + 279 WP_242101074.1 cobalamin biosynthesis protein CbiX -
MOV21_RS23165 (MOV21_23165) 10081..10524 - 444 WP_000192626.1 hypothetical protein -
MOV21_RS23170 (MOV21_23170) 10821..11003 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
MOV21_RS23175 (MOV21_23175) 11028..11465 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
MOV21_RS23180 (MOV21_23180) 11599..11784 - 186 Protein_17 hypothetical protein -
MOV21_RS23185 (MOV21_23185) 11913..12428 - 516 WP_001229189.1 hypothetical protein -
MOV21_RS23190 (MOV21_23190) 12430..12882 - 453 WP_000206702.1 hypothetical protein -
MOV21_RS23195 (MOV21_23195) 12902..13501 - 600 WP_242101075.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..58608 58608
- flank IS/Tn - - 2298..3446 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9876.23 Da        Isoelectric Point: 7.2030

>T238436 WP_022645141.1 NZ_CP093393:8365-8625 [Salmonella enterica]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EEKNAN

Download         Length: 261 bp

>T238436 NZ_LR890343:c3589696-3588779 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGTTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9407.81 Da        Isoelectric Point: 9.8120

>AT238436 WP_022645142.1 NZ_CP093393:8615-8866 [Salmonella enterica]
MLTENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp

>AT238436 NZ_LR890343:c3590460-3589702 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S5RIK4

Antitoxin

Source ID Structure
AlphaFold DB A0A2S5RIE4

References