Detailed information of TA system TA238434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4510812..4511428
• Replicon: chromosome
• Accession: NZ_CP093392
• Organism: Salmonella enterica strain P201982

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q8Z2U3
• Locus tag: MOV21_RS22155
• Protein ID: WP_000238494.1
• Coordinates: 4510812..4511186 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: MOV21_RS22160
• Protein ID: WP_001523745.1
• Coordinates: 4511186..4511428 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV21_RS22140 (4508314)	4508314..4509216	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOV21_RS22145 (4509213)	4509213..4509848	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOV21_RS22150 (4509845)	4509845..4510774	+	930	WP_242101006.1	formate dehydrogenase accessory protein FdhE	-
MOV21_RS22155 (4510812)	4510812..4511186	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	Toxin
MOV21_RS22160 (4511186)	4511186..4511428	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
MOV21_RS22165 (4511633)	4511633..4512562	+	930	WP_058661473.1	alpha/beta hydrolase	-
MOV21_RS22170 (4512648)	4512648..4512959	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOV21_RS22175 (4512956)	4512956..4513402	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MOV21_RS22180 (4513417)	4513417..4514358	-	942	WP_238727967.1	fatty acid biosynthesis protein FabY	-
MOV21_RS22185 (4514403)	4514403..4514840	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
MOV21_RS22190 (4514837)	4514837..4515709	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOV21_RS22195 (4515703)	4515703..4516302	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13908.18 Da
• Isoelectric Point: 7.3567

>T238434 WP_000238494.1 NZ_CP093392:c4511186-4510812 [Salmonella enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T238434 NZ_LR890343:c3326925-3326392 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCGAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT238434 WP_001523745.1 NZ_CP093392:c4511428-4511186 [Salmonella enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT238434 NZ_LR890343:c3327202-3326936 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A5I6CND8