Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4217844..4218625 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag MOV21_RS20890 Protein ID WP_000626104.1
Coordinates 4217844..4218335 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag MOV21_RS20895 Protein ID WP_001110452.1
Coordinates 4218332..4218625 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS20860 (4213493) 4213493..4214242 - 750 WP_001747728.1 PTS sugar transporter subunit IIC -
MOV21_RS20865 (4214295) 4214295..4214777 - 483 WP_000108906.1 PTS sugar transporter subunit IIB -
MOV21_RS20870 (4214795) 4214795..4215184 - 390 WP_001639590.1 mannose/fructose/sorbose PTS transporter subunit IIA -
MOV21_RS20875 (4215453) 4215453..4216264 + 812 Protein_4088 IS3 family transposase -
MOV21_RS20880 (4216667) 4216667..4216753 + 87 Protein_4089 porin family protein -
MOV21_RS20885 (4216844) 4216844..4217596 + 753 WP_024136566.1 non-specific acid phosphatase -
MOV21_RS20890 (4217844) 4217844..4218335 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
MOV21_RS20895 (4218332) 4218332..4218625 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
MOV21_RS20900 (4218942) 4218942..4219164 + 223 Protein_4093 hypothetical protein -
MOV21_RS20905 (4219430) 4219430..4220305 + 876 WP_000921674.1 AraC family transcriptional regulator -
MOV21_RS20910 (4220302) 4220302..4220589 + 288 WP_001269916.1 transcriptional regulator RtsB -
MOV21_RS20915 (4220729) 4220729..4221178 + 450 WP_238728174.1 Ig-like domain-containing protein -
MOV21_RS20920 (4221466) 4221466..4222371 - 906 WP_086126459.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4193067..4221178 28111
- flank IS/Tn - - 4215453..4216115 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T238433 WP_000626104.1 NZ_CP093392:c4218335-4217844 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T238433 NZ_LR890343:2726413-2726631 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT238433 WP_001110452.1 NZ_CP093392:c4218625-4218332 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT238433 NZ_LR890343:2726012-2726386 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References