Detailed information of TA system TA238432

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4203343..4205041
• Replicon: chromosome
• Accession: NZ_CP093392
• Organism: Salmonella enterica strain P201982

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2T8TGC0
• Locus tag: MOV21_RS20815
• Protein ID: WP_000365812.1
• Coordinates: 4204112..4205041 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: MOV21_RS20810
• Protein ID: WP_001134472.1
• Coordinates: 4203343..4204125 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV21_RS20785 (4200219)	4200219..4200440	-	222	WP_086126466.1	helix-turn-helix transcriptional regulator	-
MOV21_RS20790 (4200437)	4200437..4200991	-	555	WP_000907649.1	ash family protein	-
MOV21_RS20795 (4201248)	4201248..4201424	+	177	Protein_4072	XRE family transcriptional regulator	-
MOV21_RS20800 (4201483)	4201483..4202040	-	558	WP_001012368.1	hypothetical protein	-
MOV21_RS20805 (4202070)	4202070..4203041	-	972	WP_001029370.1	DUF4747 family protein	-
MOV21_RS20810 (4203343)	4203343..4204125	+	783	WP_001134472.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
MOV21_RS20815 (4204112)	4204112..4205041	+	930	WP_000365812.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MOV21_RS20820 (4205600)	4205600..4205677	-	78	Protein_4077	helix-turn-helix domain-containing protein	-
MOV21_RS20825 (4205683)	4205683..4205769	-	87	Protein_4078	reverse transcriptase/retron type	-
MOV21_RS20830 (4206429)	4206429..4209149	+	2721	WP_086126465.1	sigma 54-interacting transcriptional regulator	-
MOV21_RS20835 (4209191)	4209191..4209868	-	678	WP_000841834.1	D-allulose 6-phosphate 3-epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4193067..4221178	28111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-262)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35212.55 Da
• Isoelectric Point: 6.6435

>T238432 WP_000365812.1 NZ_CP093392:4204112-4205041 [Salmonella enterica]
MDLRDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNDR
PGISAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEIEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPITELLAPNWDTARITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLRYKQNTPDWSLYRYPEIQHLPAIRWKSRNLAVLKDKNPAKYAAAVNKLERVLEQYL

Nucleotide

• Length: 930 bp

>T238432 NZ_LR890343:c1362621-1361299 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29343.73 Da
• Isoelectric Point: 8.1107

>AT238432 WP_001134472.1 NZ_CP093392:4203343-4204125 [Salmonella enterica]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRMAGLT
SLALQGYAHYTEPGRPQVWLALPAYAKLPGWFVAFEQSAMFVTLYTSGLTVDITPFTTKLNIGDRQLIGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT238432 NZ_LR890343:c1362887-1362621 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: A0A2T8TGC0