Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4087715..4088231 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name relE Uniprot ID A0A2T8TGU4
Locus tag MOV21_RS20200 Protein ID WP_000220576.1
Coordinates 4087715..4087999 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MOV21_RS20205 Protein ID WP_000212724.1
Coordinates 4087989..4088231 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS20185 (4082833) 4082833..4084485 + 1653 WP_000155063.1 alpha,alpha-phosphotrehalase -
MOV21_RS20190 (4084894) 4084894..4087032 + 2139 WP_086126515.1 anaerobic ribonucleoside-triphosphate reductase -
MOV21_RS20195 (4087247) 4087247..4087711 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOV21_RS20200 (4087715) 4087715..4087999 - 285 WP_000220576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOV21_RS20205 (4087989) 4087989..4088231 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOV21_RS20210 (4088309) 4088309..4090221 - 1913 Protein_3959 BglG family transcription antiterminator -
MOV21_RS20215 (4090238) 4090238..4090978 - 741 WP_000779265.1 KDGP aldolase family protein -
MOV21_RS20220 (4090975) 4090975..4092093 - 1119 WP_001139180.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOV21_RS20225 (4092077) 4092077..4093210 - 1134 WP_000459931.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10855.65 Da        Isoelectric Point: 9.8739

>T238431 WP_000220576.1 NZ_CP093392:c4087999-4087715 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T238431 NZ_LR890343:1127172-1127489 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT238431 WP_000212724.1 NZ_CP093392:c4088231-4087989 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT238431 NZ_LR890343:1127565-1127861 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCCGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCAGCCAACCGGTGCAGCCAGAAAA
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TGU4

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References