Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3429829..3430449 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOV21_RS17145 Protein ID WP_001280991.1
Coordinates 3430231..3430449 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOV21_RS17140 Protein ID WP_000344807.1
Coordinates 3429829..3430203 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS17130 (3424968) 3424968..3426161 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOV21_RS17135 (3426184) 3426184..3429333 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOV21_RS17140 (3429829) 3429829..3430203 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOV21_RS17145 (3430231) 3430231..3430449 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOV21_RS17150 (3430629) 3430629..3431180 + 552 WP_001278792.1 maltose O-acetyltransferase -
MOV21_RS17155 (3431298) 3431298..3431768 + 471 WP_000136183.1 YlaC family protein -
MOV21_RS17160 (3431823) 3431823..3431963 - 141 WP_001197748.1 type B 50S ribosomal protein L36 -
MOV21_RS17165 (3431969) 3431969..3432229 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
MOV21_RS17170 (3432454) 3432454..3434004 + 1551 WP_000213153.1 EAL domain-containing protein -
MOV21_RS17180 (3434235) 3434235..3434624 + 390 WP_000961283.1 MGMT family protein -
MOV21_RS17185 (3434657) 3434657..3435226 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238429 WP_001280991.1 NZ_CP093392:3430231-3430449 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238429 NZ_LR890337:21548-21706 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238429 WP_000344807.1 NZ_CP093392:3429829-3430203 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238429 NZ_LR890337:21437-21502 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References