Detailed information of TA system TA238419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 942385..943199
• Replicon: chromosome
• Accession: NZ_CP093392
• Organism: Salmonella enterica strain P201982

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: MOV21_RS04525
• Protein ID: WP_086126752.1
• Coordinates: 942385..942912 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: MOV21_RS04530
• Protein ID: WP_000855694.1
• Coordinates: 942909..943199 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV21_RS04505 (937685)	937685..940252	-	2568	WP_050187062.1	DNA mismatch repair protein MutS	-
MOV21_RS04510 (940411)	940411..940932	+	522	WP_000858994.1	hypothetical protein	-
MOV21_RS04515 (941104)	941104..941760	-	657	WP_000420459.1	protein-serine/threonine phosphatase	-
MOV21_RS04520 (942110)	942110..942312	+	203	Protein_888	IS5/IS1182 family transposase	-
MOV21_RS04525 (942385)	942385..942912	-	528	WP_086126752.1	GNAT family N-acetyltransferase	Toxin
MOV21_RS04530 (942909)	942909..943199	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
MOV21_RS04535 (943469)	943469..943669	-	201	Protein_891	transposase	-
MOV21_RS04540 (943910)	943910..944236	+	327	WP_086126753.1	hypothetical protein	-
MOV21_RS04545 (944509)	944509..944855	-	347	Protein_893	DUF1493 family protein	-
MOV21_RS04550 (944840)	944840..945289	-	450	WP_079959869.1	hypothetical protein	-
MOV21_RS04555 (945721)	945721..946164	-	444	WP_086126754.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
MOV21_RS04560 (946622)	946622..947272	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	941104..952585	11481
	-	flank	IS/Tn	-	-	942136..942312	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19038.89 Da
• Isoelectric Point: 9.6420

>T238419 WP_086126752.1 NZ_CP093392:c942912-942385 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIPAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T238419 NZ_LR890334:c4595675-4595457 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT238419 WP_000855694.1 NZ_CP093392:c943199-942909 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT238419 NZ_LR890334:c4596075-4595701 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7