Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 797832..798457 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name vapC Uniprot ID A0A2T8TEJ4
Locus tag MOV21_RS03880 Protein ID WP_000911339.1
Coordinates 798059..798457 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2T8TEJ6
Locus tag MOV21_RS03875 Protein ID WP_000557547.1
Coordinates 797832..798059 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS03845 (792895) 792895..793993 + 1099 WP_010989230.1 peptide chain release factor 2 -
MOV21_RS03850 (794003) 794003..795520 + 1518 WP_000003339.1 lysine--tRNA ligase -
MOV21_RS03855 (795596) 795596..796141 - 546 WP_000133991.1 isopentenyl-diphosphate Delta-isomerase -
MOV21_RS03860 (796406) 796406..797164 + 759 WP_000244328.1 amidase activator ActS -
MOV21_RS03870 (797410) 797410..797623 - 214 Protein_760 hypothetical protein -
MOV21_RS03875 (797832) 797832..798059 + 228 WP_000557547.1 toxin-antitoxin system antitoxin VapB Antitoxin
MOV21_RS03880 (798059) 798059..798457 + 399 WP_000911339.1 tRNA(fMet)-specific endonuclease VapC Toxin
MOV21_RS03885 (799264) 799264..799800 + 537 WP_001038505.1 STM3031 family outer membrane protein -
MOV21_RS03890 (799847) 799847..800479 + 633 WP_000835261.1 YfdX family protein -
MOV21_RS03895 (801198) 801198..801788 + 591 WP_001244641.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 797832..807615 9783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15043.39 Da        Isoelectric Point: 7.7785

>T238418 WP_000911339.1 NZ_CP093392:798059-798457 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHVRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T238418 NZ_LR890334:4400114-4400512 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8572.55 Da        Isoelectric Point: 4.7318

>AT238418 WP_000557547.1 NZ_CP093392:797832-798059 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEDASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT238418 NZ_LR890334:4399818-4400111 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TEJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T8TEJ6

References