Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 194299..195059 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name tacT Uniprot ID A0A2T8TB76
Locus tag MOV21_RS00925 Protein ID WP_000533914.1
Coordinates 194574..195059 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MOV21_RS00920 Protein ID WP_000965886.1
Coordinates 194299..194586 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS00900 (189704) 189704..190615 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
MOV21_RS00905 (190625) 190625..192694 + 2070 WP_001291749.1 glycine--tRNA ligase subunit beta -
MOV21_RS00910 (193084) 193084..193512 + 429 Protein_182 IS3 family transposase -
MOV21_RS00915 (193654) 193654..194121 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MOV21_RS00920 (194299) 194299..194586 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MOV21_RS00925 (194574) 194574..195059 + 486 WP_000533914.1 GNAT family N-acetyltransferase Toxin
MOV21_RS00930 (195432) 195432..195971 - 540 WP_000047139.1 copper-binding periplasmic metallochaperone CueP -
MOV21_RS00935 (196148) 196148..196360 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MOV21_RS00940 (196648) 196648..196938 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MOV21_RS00945 (197377) 197377..198087 + 711 WP_080097268.1 DUF3053 domain-containing protein -
MOV21_RS00950 (198137) 198137..199111 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
MOV21_RS00955 (199330) 199330..199992 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.36 Da        Isoelectric Point: 9.5819

>T238415 WP_000533914.1 NZ_CP093392:194574-195059 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTQQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T238415 NZ_LR890334:c4030214-4029957 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT238415 WP_000965886.1 NZ_CP093392:194299-194586 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT238415 NZ_LR890334:c4029945-4029394 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TB76

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References