Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4228132..4228913 Replicon chromosome
Accession NZ_CP093391
Organism Salmonella enterica strain P287611

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag MOV20_RS20920 Protein ID WP_000626104.1
Coordinates 4228132..4228623 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag MOV20_RS20925 Protein ID WP_001110452.1
Coordinates 4228620..4228913 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV20_RS20890 (4223781) 4223781..4224530 - 750 WP_001747728.1 PTS sugar transporter subunit IIC -
MOV20_RS20895 (4224583) 4224583..4225065 - 483 WP_000108906.1 PTS sugar transporter subunit IIB -
MOV20_RS20900 (4225083) 4225083..4225472 - 390 WP_001639590.1 mannose/fructose/sorbose PTS transporter subunit IIA -
MOV20_RS20905 (4225741) 4225741..4226552 + 812 Protein_4094 IS3 family transposase -
MOV20_RS20910 (4226955) 4226955..4227041 + 87 Protein_4095 porin family protein -
MOV20_RS20915 (4227132) 4227132..4227884 + 753 WP_024136566.1 non-specific acid phosphatase -
MOV20_RS20920 (4228132) 4228132..4228623 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
MOV20_RS20925 (4228620) 4228620..4228913 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
MOV20_RS20930 (4229230) 4229230..4229452 + 223 Protein_4099 hypothetical protein -
MOV20_RS20935 (4229718) 4229718..4230593 + 876 WP_000921674.1 AraC family transcriptional regulator -
MOV20_RS20940 (4230590) 4230590..4230877 + 288 WP_001269916.1 transcriptional regulator RtsB -
MOV20_RS20945 (4231017) 4231017..4231466 + 450 WP_238728174.1 Ig-like domain-containing protein -
MOV20_RS20950 (4231754) 4231754..4232659 - 906 WP_086126459.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4203355..4231466 28111
- flank IS/Tn - - 4225741..4226403 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T238412 WP_000626104.1 NZ_CP093391:c4228623-4228132 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T238412 NZ_LR890334:3719086-3719472 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT238412 WP_001110452.1 NZ_CP093391:c4228913-4228620 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT238412 NZ_LR890334:3718484-3719056 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAATT
GAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATTTGATCTCGCAAATATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References