Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4213631..4215329 | Replicon | chromosome |
| Accession | NZ_CP093391 | ||
| Organism | Salmonella enterica strain P287611 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A2T8TGC0 |
| Locus tag | MOV20_RS20845 | Protein ID | WP_000365812.1 |
| Coordinates | 4214400..4215329 (+) | Length | 310 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | MOV20_RS20840 | Protein ID | WP_001134472.1 |
| Coordinates | 4213631..4214413 (+) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOV20_RS20815 (4210507) | 4210507..4210728 | - | 222 | WP_086126466.1 | helix-turn-helix transcriptional regulator | - |
| MOV20_RS20820 (4210725) | 4210725..4211279 | - | 555 | WP_000907649.1 | ash family protein | - |
| MOV20_RS20825 (4211536) | 4211536..4211712 | + | 177 | Protein_4078 | XRE family transcriptional regulator | - |
| MOV20_RS20830 (4211771) | 4211771..4212328 | - | 558 | WP_001012368.1 | hypothetical protein | - |
| MOV20_RS20835 (4212358) | 4212358..4213329 | - | 972 | WP_001029370.1 | DUF4747 family protein | - |
| MOV20_RS20840 (4213631) | 4213631..4214413 | + | 783 | WP_001134472.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| MOV20_RS20845 (4214400) | 4214400..4215329 | + | 930 | WP_000365812.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| MOV20_RS20850 (4215888) | 4215888..4215965 | - | 78 | Protein_4083 | helix-turn-helix domain-containing protein | - |
| MOV20_RS20855 (4215971) | 4215971..4216057 | - | 87 | Protein_4084 | reverse transcriptase/retron type | - |
| MOV20_RS20860 (4216717) | 4216717..4219437 | + | 2721 | WP_086126465.1 | sigma 54-interacting transcriptional regulator | - |
| MOV20_RS20865 (4219479) | 4219479..4220156 | - | 678 | WP_000841834.1 | D-allulose 6-phosphate 3-epimerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4203355..4231466 | 28111 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 310 a.a. Molecular weight: 35212.55 Da Isoelectric Point: 6.6435
>T238411 WP_000365812.1 NZ_CP093391:4214400-4215329 [Salmonella enterica]
MDLRDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNDR
PGISAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEIEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPITELLAPNWDTARITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLRYKQNTPDWSLYRYPEIQHLPAIRWKSRNLAVLKDKNPAKYAAAVNKLERVLEQYL
MDLRDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNDR
PGISAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEIEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPITELLAPNWDTARITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLRYKQNTPDWSLYRYPEIQHLPAIRWKSRNLAVLKDKNPAKYAAAVNKLERVLEQYL
Download Length: 930 bp
>T238411 NZ_LR890334:3502797-3503108 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 261 a.a. Molecular weight: 29343.73 Da Isoelectric Point: 8.1107
>AT238411 WP_001134472.1 NZ_CP093391:4213631-4214413 [Salmonella enterica]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRMAGLT
SLALQGYAHYTEPGRPQVWLALPAYAKLPGWFVAFEQSAMFVTLYTSGLTVDITPFTTKLNIGDRQLIGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRMAGLT
SLALQGYAHYTEPGRPQVWLALPAYAKLPGWFVAFEQSAMFVTLYTSGLTVDITPFTTKLNIGDRQLIGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA
Download Length: 783 bp
>AT238411 NZ_LR890334:3503109-3503399 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|