23841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 382073..382691 Replicon chromosome
Accession NC_012759
Organism Escherichia coli BW2952

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag BWG_RS01905 Protein ID WP_001290581.1
Coordinates 382073..382291 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag BWG_RS01910 Protein ID WP_000344800.1
Coordinates 382317..382691 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWG_RS01875 (BWG_0335) 377362..377934 + 573 WP_000779842.1 YbaY family lipoprotein -
BWG_RS01880 (BWG_0336) 377965..378276 - 312 WP_000409911.1 MGMT family protein -
BWG_RS01885 (BWG_0337) 378655..379008 + 354 WP_000878140.1 DUF1428 domain-containing protein -
BWG_RS01890 (BWG_0338) 379050..380600 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
BWG_RS01895 (BWG_0339) 380764..381234 - 471 WP_000136192.1 YlaC family protein -
BWG_RS01900 (BWG_0340) 381350..381901 - 552 WP_000102564.1 maltose O-acetyltransferase -
BWG_RS01905 (BWG_0341) 382073..382291 - 219 WP_001290581.1 hemolysin expression modulator Hha Toxin
BWG_RS01910 (BWG_0342) 382317..382691 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
BWG_RS01915 (BWG_0343) 383237..386386 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
BWG_RS01920 (BWG_0344) 386409..387602 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T23841 WP_001290581.1 NC_012759:c382291-382073 [Escherichia coli BW2952]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T23841 NC_012759:c382291-382073 [Escherichia coli BW2952]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT23841 WP_000344800.1 NC_012759:c382691-382317 [Escherichia coli BW2952]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT23841 NC_012759:c382691-382317 [Escherichia coli BW2952]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References