Detailed information of TA system TA238398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 942448..943262
• Replicon: chromosome
• Accession: NZ_CP093391
• Organism: Salmonella enterica strain P287611

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: MOV20_RS04525
• Protein ID: WP_086126752.1
• Coordinates: 942448..942975 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: MOV20_RS04530
• Protein ID: WP_000855694.1
• Coordinates: 942972..943262 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV20_RS04505 (937748)	937748..940315	-	2568	WP_050187062.1	DNA mismatch repair protein MutS	-
MOV20_RS04510 (940474)	940474..940995	+	522	WP_000858994.1	hypothetical protein	-
MOV20_RS04515 (941167)	941167..941823	-	657	WP_000420459.1	protein-serine/threonine phosphatase	-
MOV20_RS04520 (942173)	942173..942375	+	203	Protein_888	IS5/IS1182 family transposase	-
MOV20_RS04525 (942448)	942448..942975	-	528	WP_086126752.1	GNAT family N-acetyltransferase	Toxin
MOV20_RS04530 (942972)	942972..943262	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
MOV20_RS04535 (943532)	943532..943732	-	201	Protein_891	transposase	-
MOV20_RS04540 (943973)	943973..944299	+	327	WP_086126753.1	hypothetical protein	-
MOV20_RS04545 (944572)	944572..944918	-	347	Protein_893	DUF1493 family protein	-
MOV20_RS04550 (944903)	944903..945352	-	450	WP_079959869.1	hypothetical protein	-
MOV20_RS04555 (945784)	945784..946227	-	444	WP_086126754.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
MOV20_RS04560 (946685)	946685..947335	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	941167..952648	11481
	-	flank	IS/Tn	-	-	942199..942375	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19038.89 Da
• Isoelectric Point: 9.6420

>T238398 WP_086126752.1 NZ_CP093391:c942975-942448 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIPAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T238398 NZ_LR890334:c203624-203130 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT238398 WP_000855694.1 NZ_CP093391:c943262-942972 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT238398 NZ_LR890334:c203914-203621 [Escherichia coli]
ATGGCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATAGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCTCCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7