Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788072..788732 Replicon chromosome
Accession NZ_CP093391
Organism Salmonella enterica strain P287611

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag MOV20_RS03820 Protein ID WP_000244761.1
Coordinates 788319..788732 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MOV20_RS03815 Protein ID WP_000351186.1
Coordinates 788072..788338 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV20_RS03795 (784000) 784000..785433 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
MOV20_RS03800 (785592) 785592..785903 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MOV20_RS03805 (786067) 786067..786726 + 660 WP_000250289.1 hemolysin III family protein -
MOV20_RS03810 (786842) 786842..787822 - 981 WP_000874166.1 tRNA-modifying protein YgfZ -
MOV20_RS03815 (788072) 788072..788338 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MOV20_RS03820 (788319) 788319..788732 + 414 WP_000244761.1 protein YgfX Toxin
MOV20_RS03825 (788785) 788785..789306 - 522 WP_001055885.1 flavodoxin FldB -
MOV20_RS03830 (789419) 789419..790315 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MOV20_RS03835 (790339) 790339..791052 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOV20_RS03840 (791058) 791058..792791 + 1734 WP_086126359.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T238396 WP_000244761.1 NZ_CP093391:788319-788732 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T238396 NZ_LR890328:69663-69812 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT238396 WP_000351186.1 NZ_CP093391:788072-788338 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238396 NZ_LR890328:c69618-69559 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References