Detailed information of TA system TA238392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4519937..4520553
• Replicon: chromosome
• Accession: NZ_CP093390
• Organism: Salmonella enterica strain P289597

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q8Z2U3
• Locus tag: MOV19_RS22140
• Protein ID: WP_000238494.1
• Coordinates: 4519937..4520311 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: MOV19_RS22145
• Protein ID: WP_001523745.1
• Coordinates: 4520311..4520553 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV19_RS22125 (4517439)	4517439..4518341	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOV19_RS22130 (4518338)	4518338..4518973	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOV19_RS22135 (4518970)	4518970..4519899	+	930	WP_000027734.1	formate dehydrogenase accessory protein FdhE	-
MOV19_RS22140 (4519937)	4519937..4520311	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	Toxin
MOV19_RS22145 (4520311)	4520311..4520553	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
MOV19_RS22150 (4520758)	4520758..4521687	+	930	WP_058661473.1	alpha/beta hydrolase	-
MOV19_RS22155 (4521773)	4521773..4522084	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOV19_RS22160 (4522081)	4522081..4522527	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MOV19_RS22165 (4522542)	4522542..4523483	-	942	WP_238727967.1	fatty acid biosynthesis protein FabY	-
MOV19_RS22170 (4523528)	4523528..4523965	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
MOV19_RS22175 (4523962)	4523962..4524834	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOV19_RS22180 (4524828)	4524828..4525427	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13908.18 Da
• Isoelectric Point: 7.3567

>T238392 WP_000238494.1 NZ_CP093390:c4520311-4519937 [Salmonella enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T238392 NZ_LR890327:37861-38391 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT238392 WP_001523745.1 NZ_CP093390:c4520553-4520311 [Salmonella enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT238392 NZ_LR890327:37588-37857 [Escherichia coli]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A5I6CND8