Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4226938..4227719 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag MOV19_RS20875 Protein ID WP_000626104.1
Coordinates 4226938..4227429 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag MOV19_RS20880 Protein ID WP_001110452.1
Coordinates 4227426..4227719 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS20845 (4222587) 4222587..4223336 - 750 WP_001747728.1 PTS sugar transporter subunit IIC -
MOV19_RS20850 (4223389) 4223389..4223871 - 483 WP_000108906.1 PTS sugar transporter subunit IIB -
MOV19_RS20855 (4223889) 4223889..4224278 - 390 WP_001639590.1 mannose/fructose/sorbose PTS transporter subunit IIA -
MOV19_RS20860 (4224547) 4224547..4225358 + 812 Protein_4087 IS3 family transposase -
MOV19_RS20865 (4225761) 4225761..4225847 + 87 Protein_4088 porin family protein -
MOV19_RS20870 (4225938) 4225938..4226690 + 753 WP_024136566.1 non-specific acid phosphatase -
MOV19_RS20875 (4226938) 4226938..4227429 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
MOV19_RS20880 (4227426) 4227426..4227719 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
MOV19_RS20885 (4228036) 4228036..4228258 + 223 Protein_4092 hypothetical protein -
MOV19_RS20890 (4228524) 4228524..4229399 + 876 WP_000921674.1 AraC family transcriptional regulator -
MOV19_RS20895 (4229396) 4229396..4229683 + 288 WP_001269916.1 transcriptional regulator RtsB -
MOV19_RS20900 (4229823) 4229823..4230272 + 450 WP_238728174.1 Ig-like domain-containing protein -
MOV19_RS20905 (4230560) 4230560..4231465 - 906 WP_086126459.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4202161..4230272 28111
- flank IS/Tn - - 4224547..4225209 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T238391 WP_000626104.1 NZ_CP093390:c4227429-4226938 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T238391 NZ_LR890327:31162-31437 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT238391 WP_001110452.1 NZ_CP093390:c4227719-4227426 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT238391 NZ_LR890327:30878-31162 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References