Detailed information of TA system TA238390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4212437..4214135
• Replicon: chromosome
• Accession: NZ_CP093390
• Organism: Salmonella enterica strain P289597

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2T8TGC0
• Locus tag: MOV19_RS20800
• Protein ID: WP_000365812.1
• Coordinates: 4213206..4214135 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: MOV19_RS20795
• Protein ID: WP_001134472.1
• Coordinates: 4212437..4213219 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV19_RS20770 (4209313)	4209313..4209534	-	222	WP_086126466.1	helix-turn-helix transcriptional regulator	-
MOV19_RS20775 (4209531)	4209531..4210085	-	555	WP_000907649.1	ash family protein	-
MOV19_RS20780 (4210342)	4210342..4210518	+	177	Protein_4071	XRE family transcriptional regulator	-
MOV19_RS20785 (4210577)	4210577..4211134	-	558	WP_001012368.1	hypothetical protein	-
MOV19_RS20790 (4211164)	4211164..4212135	-	972	WP_001029370.1	DUF4747 family protein	-
MOV19_RS20795 (4212437)	4212437..4213219	+	783	WP_001134472.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
MOV19_RS20800 (4213206)	4213206..4214135	+	930	WP_000365812.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MOV19_RS20805 (4214694)	4214694..4214771	-	78	Protein_4076	helix-turn-helix domain-containing protein	-
MOV19_RS20810 (4214777)	4214777..4214863	-	87	Protein_4077	reverse transcriptase/retron type	-
MOV19_RS20815 (4215523)	4215523..4218243	+	2721	WP_086126465.1	sigma 54-interacting transcriptional regulator	-
MOV19_RS20820 (4218285)	4218285..4218962	-	678	WP_000841834.1	D-allulose 6-phosphate 3-epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4202161..4230272	28111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-262)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35212.55 Da
• Isoelectric Point: 6.6435

>T238390 WP_000365812.1 NZ_CP093390:4213206-4214135 [Salmonella enterica]
MDLRDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNDR
PGISAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEIEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPITELLAPNWDTARITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLRYKQNTPDWSLYRYPEIQHLPAIRWKSRNLAVLKDKNPAKYAAAVNKLERVLEQYL

Nucleotide

• Length: 930 bp

>T238390 NZ_LR890326:c4714335-4714228 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29343.73 Da
• Isoelectric Point: 8.1107

>AT238390 WP_001134472.1 NZ_CP093390:4212437-4213219 [Salmonella enterica]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRMAGLT
SLALQGYAHYTEPGRPQVWLALPAYAKLPGWFVAFEQSAMFVTLYTSGLTVDITPFTTKLNIGDRQLIGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT238390 NZ_LR890326:4714383-4714449 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A2T8TGC0