Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4096802..4097318 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name relE Uniprot ID A0A2T8TGU4
Locus tag MOV19_RS20185 Protein ID WP_000220576.1
Coordinates 4096802..4097086 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MOV19_RS20190 Protein ID WP_000212724.1
Coordinates 4097076..4097318 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS20170 (4091920) 4091920..4093572 + 1653 WP_000155063.1 alpha,alpha-phosphotrehalase -
MOV19_RS20175 (4093981) 4093981..4096119 + 2139 WP_086126515.1 anaerobic ribonucleoside-triphosphate reductase -
MOV19_RS20180 (4096334) 4096334..4096798 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOV19_RS20185 (4096802) 4096802..4097086 - 285 WP_000220576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOV19_RS20190 (4097076) 4097076..4097318 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOV19_RS20195 (4097396) 4097396..4099308 - 1913 Protein_3958 BglG family transcription antiterminator -
MOV19_RS20200 (4099325) 4099325..4100065 - 741 WP_000779265.1 KDGP aldolase family protein -
MOV19_RS20205 (4100062) 4100062..4101180 - 1119 WP_001139180.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOV19_RS20210 (4101164) 4101164..4102297 - 1134 WP_000459931.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10855.65 Da        Isoelectric Point: 9.8739

>T238389 WP_000220576.1 NZ_CP093390:c4097086-4096802 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T238389 NZ_LR890326:c4713851-4713744 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT238389 WP_000212724.1 NZ_CP093390:c4097318-4097076 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT238389 NZ_LR890326:4713899-4713965 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TGU4

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References