Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4039113..4039663 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MOV19_RS19900 Protein ID WP_001199743.1
Coordinates 4039113..4039421 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MOV19_RS19905 Protein ID WP_000016244.1
Coordinates 4039424..4039663 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS19890 (4034517) 4034517..4038032 - 3516 WP_238727947.1 AAA domain-containing protein -
MOV19_RS19895 (4038394) 4038394..4038678 - 285 Protein_3900 Arm DNA-binding domain-containing protein -
MOV19_RS19900 (4039113) 4039113..4039421 - 309 WP_001199743.1 CcdB family protein Toxin
MOV19_RS19905 (4039424) 4039424..4039663 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MOV19_RS19910 (4039776) 4039776..4040024 - 249 WP_020898324.1 ribbon-helix-helix protein, CopG family -
MOV19_RS19915 (4040089) 4040089..4040922 - 834 WP_193432508.1 DUF4942 domain-containing protein -
MOV19_RS19920 (4041063) 4041063..4041685 - 623 Protein_3905 metallophosphoesterase -
MOV19_RS19925 (4041727) 4041727..4042080 - 354 WP_001181796.1 TA system toxin CbtA family protein -
MOV19_RS19930 (4042095) 4042095..4042423 - 329 Protein_3907 type IV toxin-antitoxin system YeeU family antitoxin -
MOV19_RS19935 (4042447) 4042447..4042668 - 222 WP_000691987.1 DUF987 family protein -
MOV19_RS19940 (4042665) 4042665..4043165 - 501 WP_000100794.1 DNA repair protein RadC -
MOV19_RS19945 (4043184) 4043184..4044005 - 822 WP_000197551.1 DUF932 domain-containing protein -
MOV19_RS19950 (4044089) 4044089..4044451 - 363 WP_000393539.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4026422..4055370 28948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T238388 WP_001199743.1 NZ_CP093390:c4039421-4039113 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T238388 NZ_LR890326:c4713367-4713260 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT238388 WP_000016244.1 NZ_CP093390:c4039663-4039424 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT238388 NZ_LR890326:4713424-4713479 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References