Detailed information of TA system TA238377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 942627..943441
• Replicon: chromosome
• Accession: NZ_CP093390
• Organism: Salmonella enterica strain P289597

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: MOV19_RS04530
• Protein ID: WP_086126752.1
• Coordinates: 942627..943154 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: MOV19_RS04535
• Protein ID: WP_000855694.1
• Coordinates: 943151..943441 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV19_RS04510 (937927)	937927..940494	-	2568	WP_050187062.1	DNA mismatch repair protein MutS	-
MOV19_RS04515 (940653)	940653..941174	+	522	WP_000858994.1	hypothetical protein	-
MOV19_RS04520 (941346)	941346..942002	-	657	WP_000420459.1	protein-serine/threonine phosphatase	-
MOV19_RS04525 (942352)	942352..942554	+	203	Protein_889	IS5/IS1182 family transposase	-
MOV19_RS04530 (942627)	942627..943154	-	528	WP_086126752.1	GNAT family N-acetyltransferase	Toxin
MOV19_RS04535 (943151)	943151..943441	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
MOV19_RS04540 (943711)	943711..943911	-	201	Protein_892	transposase	-
MOV19_RS04545 (944152)	944152..944478	+	327	WP_086126753.1	hypothetical protein	-
MOV19_RS04550 (944751)	944751..945097	-	347	Protein_894	DUF1493 family protein	-
MOV19_RS04555 (945082)	945082..945531	-	450	WP_079959869.1	hypothetical protein	-
MOV19_RS04560 (945963)	945963..946406	-	444	WP_086126754.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
MOV19_RS04565 (946864)	946864..947514	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	941346..952827	11481
	-	flank	IS/Tn	-	-	942378..942554	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19038.89 Da
• Isoelectric Point: 9.6420

>T238377 WP_086126752.1 NZ_CP093390:c943154-942627 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIPAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T238377 NZ_LR890326:1724774-1725028 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT238377 WP_000855694.1 NZ_CP093390:c943441-943151 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT238377 NZ_LR890326:1724526-1724777 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7