Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 797951..798576 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name vapC Uniprot ID A0A2T8TEJ4
Locus tag MOV19_RS03880 Protein ID WP_000911339.1
Coordinates 798178..798576 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2T8TEJ6
Locus tag MOV19_RS03875 Protein ID WP_000557547.1
Coordinates 797951..798178 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS03845 (793014) 793014..794112 + 1099 WP_010989230.1 peptide chain release factor 2 -
MOV19_RS03850 (794122) 794122..795639 + 1518 WP_000003339.1 lysine--tRNA ligase -
MOV19_RS03855 (795715) 795715..796260 - 546 WP_000133991.1 isopentenyl-diphosphate Delta-isomerase -
MOV19_RS03860 (796525) 796525..797283 + 759 WP_000244328.1 amidase activator ActS -
MOV19_RS03870 (797529) 797529..797742 - 214 Protein_760 hypothetical protein -
MOV19_RS03875 (797951) 797951..798178 + 228 WP_000557547.1 toxin-antitoxin system antitoxin VapB Antitoxin
MOV19_RS03880 (798178) 798178..798576 + 399 WP_000911339.1 tRNA(fMet)-specific endonuclease VapC Toxin
MOV19_RS03885 (799383) 799383..799919 + 537 WP_001038505.1 STM3031 family outer membrane protein -
MOV19_RS03890 (799966) 799966..800598 + 633 WP_000835261.1 YfdX family protein -
MOV19_RS03895 (801317) 801317..801907 + 591 WP_001244641.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 797951..807734 9783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15043.39 Da        Isoelectric Point: 7.7785

>T238376 WP_000911339.1 NZ_CP093390:798178-798576 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHVRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T238376 NZ_LR890326:1724526-1724777 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8572.55 Da        Isoelectric Point: 4.7318

>AT238376 WP_000557547.1 NZ_CP093390:797951-798178 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEDASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT238376 NZ_LR890326:1724774-1725028 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TEJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T8TEJ6

References